01 - Preheat oven to 350°F. Lightly grease a 9x13 inch baking dish.
02 - Boil elbow macaroni in well-salted water until just al dente. Drain and set aside.
03 - Melt 3 tablespoons unsalted butter in a large saucepan over medium heat. Whisk in all-purpose flour and cook for 1 to 2 minutes until lightly golden.
04 - Gradually whisk in whole milk, stirring constantly to prevent lumps. Add Dijon mustard, garlic powder, onion powder, black pepper, and salt. Simmer gently for 4 to 5 minutes until slightly thickened.
05 - Remove saucepan from heat. Stir in sharp cheddar, Gruyère, and Parmesan cheeses until fully melted and smooth.
06 - Add drained macaroni to the cheese sauce, stirring until evenly coated.
07 - Transfer macaroni and cheese mixture to the prepared baking dish.
08 - In a bowl, combine panko breadcrumbs, melted butter, and Parmesan cheese. Sprinkle mixture evenly over the macaroni.
09 - Bake for 25 to 30 minutes until topping is golden and mixture is bubbling. Allow to rest for 5 minutes before serving. Garnish with chopped parsley if desired.